CTNNB1 Recombinant Protein
Product Sizes
10 ug
OPCD02508-10UG
200 ug
OPCD02508-200UG
50 ug
OPCD02508-50UG
About this Product
- SKU:
- OPCD02508
- Additional Names:
- beta-catenin;catenin (cadherin associated protein), beta 1, 88kDa;catenin beta-1;Catnb.|catenin beta 1
- Application:
- Control, SDS-PAGE, Western Blot
- Buffer:
- Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- Concentration:
- 200 ug/ml
- Extra Details:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
- Formulation:
- Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- Immunogen:
- Ctnnb1
- Molecular Weight:
- 33kDa
- Purity:
- >95%
- Reactivities:
- Rat
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php