Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) Small/secreted Glycoprotein (sGP) Protein, His Tag
Product Sizes
50 ug
£307.00
BEP-V5220-50UG
1 mg
£2573.00
BEP-V5220-1MG
About this Product
- SKU:
- BEP-V5220
- Additional Names:
- 2)|Envelope glycoprotein|GP|GP(1
- Buffer:
- PBS
- Extra Details:
- EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
- Immunogen:
- Small secreted glycoprotein/sGP (EBOV)
- Molecular Weight:
- 34.3 kda
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
