VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434)
Produktgrößen
100ug
£761,00
V2700-35-100UG
Über dieses Produkt
- SKU:
- V2700-35
- Anwendung:
- Western Blot
- Klonalität:
- Polyclonal
- Weitere Details:
- Brorin (also VWC2, von Willebrand Factor C domain-containing protein 2) is a secreted, 48-49 kD member of the chordin family of proteins. It is expressed by neurons in multiple sites, and serves to sequester BMP family proteins such as BMP-2 and BMP-6. BMP antagonism is suggested to generate neurons from neural precursor cells at the expense of astrocytes. Human Brorin precursor is 325aa in length. It contains a 27aa signal sequence, one poly-Ala region (aa120-127), and two von Willebrand factor C domains (aa153-212 and 216-274) that likely serve as BMP interaction sites. Over aa28-325, human Brorin shares 90% aa identity with mouse Brorin. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Sheep
- Immunogen:
- Recombinant protein corresponding to Ser28-Met325 from human VWC2, expressed in NSO cells
- Isotyp:
- IgG
- Physischer Zustand:
- Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
- Reinheit:
- Purified by immunoaffinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes human Brorin. ~50% cross-reactivity with recombinant mouse Brorin
- Quelle:
- human
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Polyclonal Antibody