SULT2B1 (Sulfotransferase Family, Cytosolic, 2B, Member 1, Alcohol Sulfotransferase, HSST2, Hydroxysteroid Sulfotransferase 2, ST2B1, Sulfotransferase 2B1)
Produktgrößen
100ug
£748,00
S8022-05B-100UG
Über dieses Produkt
- SKU:
- S8022-05B
- Anwendung:
- Immunohistochemistry
- translate.label.attr.clone:
- 11n179
- Klonalität:
- Monoclonal
- Weitere Details:
- SulT2B1 is a 45-48kD member of the sulfotransferase 1 family of enzymes. SulT2B1 is widely expressed, being found in platelets, stratum granulosum keratinocytes, breast and prostatic epithelium, and syncytiotrophoblast cells. SulT2B1 catalyzes the sulfonation of DHEA, a precursor for sex steroids, and cholesterol, which supports stratification of the epidermis. Human SulT2B1 is 365aa in length. There are PAPS binding sites between aa70-75 and 147-155, a myristoylation motif between aa255-259, and a Pro-rich region between aa305-364 that may extend enzyme half-life. There is one 43kD splice form (ST2B1a) that shows an eight aa substitution for aa1-23. It is expressed in fetal brain and generates pregnenolone sulfate, a steroid that modulates neurotransmitters. Full-length human SulT2B1 shares 71% aa identity with mouse SulT2B1. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 8-25ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Mouse
- Immunogen:
- Recombinant corresponding to aa2-365 from human Cytosolic Sulfotransferase 2B1/SULT2B1 expressed in E. coli (O00204).
- Isotyp:
- IgG2a
- Physischer Zustand:
- Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Reinheit:
- Purified by Protein A/G affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes human SULT2B1. Species sequence homology: mouse (71%). No cross-reactivity with recombinant human SULT1A1, 1A3, 1B1, 1C4, 1E1, 2A1, or 4A1.
- Quelle:
- human
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Monoclonal Antibody