DAXX (BING2, DAP 6, DAP6, Death Domain-associated Protein 6, ETS1-associated Protein 1, EAP 1, EAP1, Fas Death Domain Associated Protein, hDaxx)
Produktgrößen
100ug
£621,00
D1150-01E-100UG
Über dieses Produkt
- SKU:
- D1150-01E
- Anwendung:
- Western Blot
- translate.label.attr.clone:
- DAXX-01
- Klonalität:
- Monoclonal
- Weitere Details:
- Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1). Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to aa558-740 at the C-terminal of human DAXX.
- Isotyp:
- IgG1
- Physischer Zustand:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
- Reinheit:
- Purified by Protein A affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes human DAXX.
- Quelle:
- human
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Monoclonal Antibody