Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin)
Produktgrößen
100ug
£876,00
C0108-38A-100UG
Über dieses Produkt
- SKU:
- C0108-38A
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Weitere Details:
- Cadherin-4 (also Retinal/R-Cadherin) is a 120kD (100kD predicted) member of the classical cadherin family of molecules. It is expressed on mammary epithelium, olfactory bulb neurons, cerebellar granule cells, vascular smooth muscle, astrocytes and pancreatic B-cells. Cadherin-4 forms both homodimers and heterodimers with N-cadherin. These complexes will oligomerize, providing sources for adhesion and migration. Cadherin-4 also binds to KLRG1 expressed on NK, T and Treg lymphocytes. Mouse cadherin-4 proprecursor is 893aa in length. It contains a 146aa propeptide aa21-166 coupled to a 746aa type I transmembrane mature protein aa 167-913. The mature region possesses a 565aa extracellular domain aa167-731 plus a 160aa cytoplasmic region aa753-913. Consistent with classical cadherins, cadherin-4 contains five cadherin repeats in the extracellular domain aa167-721. There is one potential splice form that shows a 44aa substitution for aa291-913. Over aa21-731, mouse cadherin-4 shares 98% and 93% aa identity with rat and human cadherin-4. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Immunohistochemistry: 5-15ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Sheep
- Immunogen:
- Recombinant protein corresponding to aa21-731 from mouse Cadherin-4 expressed in NS0 cell line.
- Isotyp:
- IgG
- Physischer Zustand:
- Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
- Reinheit:
- Purified by immunoaffinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes mouse Cadherin-4. Species sequence homology: Recombinant human Cadherin-4 (5%), recombinant mouse Cadherin-2 (5%), recombinant mouse E-Cadherin (<1%).
- Quelle:
- mouse
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Polyclonal Antibody