Bcl XL, phosphorlayted (Thr115)
Produktgrößen
100ug
£735,00
B0807-19G1-100UG
Über dieses Produkt
- SKU:
- B0807-19G1
- Klonalität:
- Polyclonal
- Weitere Details:
- Bcl-XL (28kD) is part of the Bcl-2 family, which are important regulators of apoptosis. Bcl-X has two isoforms, Bcl-XL (long) a 241 amino acid protein and shares significant homology with Bcl-2. Bcl-XS (short) a 178 amino acid protein lacking a 63 amino acid domain near the transmembrane region that is well conserved among members of the Bcl-2 family. Like Bcl-2, Bcl-XL has the ability to inhibit apoptosis and is widely studied for its role in tumor generation. In a recent study, analysis of Hodgkin’s disease showed that 71% of cases (114/160) showed immunohistochemical reactivity with Bcl-XL in Reed-Sternberg cells. In some cases, Bcl-XL reactivity was present in Reed-Sternberg cells that were negative for CD15 and CD30. Atypical hyperplasias (0/28) were negative for Bcl-XL. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000-1:100,000 for detection of coated peptide (100ng/well) Optimal dilutions to be determined by researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide (TSQLHITpPGTAY) derived from Bcl-xL with phosphorylation at Thr115 (KLH).
- Isotyp:
- IgG
- Physischer Zustand:
- Supplied as a lyophilized powder from 0.01M PBS, pH 7.4. Reconstitute with 100ul of sterile ddH2O.
- Reinheit:
- Purified
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes phosphorylated Bcl XL peptide.
- Quelle:
- mouse
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Polyclonal Antibody