PAPPA2 (Pappalysin 2, PAPP-A2, PAPPE, PLAC3, Placenta-Specific 3, Pregnancy-associated plasma protein A2, Pregnancy-associated plasma protein E1)
Produktgrößen
200ul
£659,00
364522-200UL
Über dieses Produkt
- SKU:
- 364522
- Anwendung:
- Immunofluorescence
- Klonalität:
- Polyclonal
- Weitere Details:
- Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45%aa identity with PAPP-A and cleaves IGFBP-2.sialic acid binding Ig-like lectin 6 (Siglec-6), a potential leptin receptor, and pappalysin-2 (PAPP-A2), a protease that cleaves IGF-binding proteins Applications: Suitable for use in Immunofluorescence and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry/Immunofluorescence: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa1309-1492 from human PAPPA2 expressed in E. coli.
- Isotyp:
- IgG
- Physischer Zustand:
- Supplied as a liquid in PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes human PAPPA2.
- Quelle:
- human
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Polyclonal Antibody