FLNa (Filamin A Alpha, ABP280, FLN-A, ABPX, FLN, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, Actin Binding Protein 280, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin)
Produktgrößen
200ul
£626,00
363127-200UL
Über dieses Produkt
- SKU:
- 363127
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence
- Klonalität:
- Polyclonal
- Weitere Details:
- Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Filamin A is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in Immunohistochemistry, Immunofluorescence and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.01-2ug/mL Immunohistochemistry: 5-20ug/mL Immunofluorescence (IC): 5-20ug/mL Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa2-274 of human FLNa, expressed in E. coli.
- Isotyp:
- IgG
- Physischer Zustand:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Recognizes human FLNa. Species Crossreactivity: mouse and rat
- Quelle:
- human
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- United States Biological
- Typ:
- Antibodies:Polyclonal Antibody