Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2)
Produktgrößen
1mg
£620,00
029414-1MG
Über dieses Produkt
- SKU:
- 029414
- CAS Number:
- 612847-09-3
- Weitere Details:
- A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. CAS No: 612847-09-3 Primary Target: Akt1, Akt2, Akt3 Solubility: DMSO (5mg/ml) Molecular Weight: ~551.6 Appearance: Supplied as a yellow solid. Purity: ≥95% (HPLC) Storage and Stability: Store at 4°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Molekulargewicht:
- 551.6
- Physischer Zustand:
- Supplied as a yellow solid.
- Reinheit:
- ≥95% (HPLC)
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 4[o]C
- Hersteller:
- United States Biological
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Inhibitors