ML323
Produktgrößen
5 mg
£168,00
F4120-5MG
Über dieses Produkt
- SKU:
- F4120
- Buffer:
- Powder; no buffer
- Weitere Details:
- ML323 is a cell permealbe, selective and highly potent inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. ML 323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting USP1-UAF1. ML323 was used at 10-30 µM in various in vitro assay.
- Molekulargewicht:
- 384.48 g/mol
- Versandbedingungen:
- Ambient
- Quelle:
- chemical synthesis
- Lagerbedingungen:
- -20 0C
- Hersteller:
- UBP Bio
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules