ONX-0914 (PR-957)
Produktgrößen
5 mg
£221,00
F1410-5MG
Über dieses Produkt
- SKU:
- F1410
- Buffer:
- Powder; no buffer
- Weitere Details:
- ONX-0914, also known as PR-957, is a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. ONX-0914 selectively inhibits low-molecular mass polypeptide-7 (LMP7), the subunit specific for the immunoproteasome that catalyzes the chymotyrpsion-like activity, with an IC50 < 100 nM. Cell culture and animal studies have shown that ONX-0914 blocks the production of proinflammatory cytokines including interleukin-6 and 17, indicating that it has potential uses in the treatment of some autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease and lupus. Dose: 0.1-0.5 μM for in vitro or cell couture assays; intravenous or subcutaneous administration at 2-10 mg/Kg daily for 5-7 days for animal studies.
- Molekulargewicht:
- 580.7 g/mol
- Versandbedingungen:
- Ambient
- Quelle:
- chemical synthesis
- Lagerbedingungen:
- -20 0C
- Hersteller:
- UBP Bio
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules