FRP-5, soluble
Produktgrößen
10 ug
£178,82
S01-077-10UG
50 ug
£307,06
S01-077-50UG
Über dieses Produkt
- SKU:
- S01-077
- Zusätzliche Namen:
- Secreted frizzled-related protein 5, Frizzled-related protein 1b, FRP-1b, Secreted apoptosis-related protein 3, SARP-3
- translate.label.attr.clone:
- (#9A52)
- Weitere Details:
- Secreted Frizzled Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists that inhibit Wnt signaling, either by directly binding to Wnt proteins to prevent their binding to Frizzled (Fz) family receptor proteins or by forming non-functional interactions with Frizzled receptors. sFRPs share homology with the cysteine-rich, extracellular domain of Frizzled proteins. sFRP-5 is secreted in a variety of embryonic and adult tissues. During embryonic development, sFRP-5 regulates formation of the retina, brain, trunk, foregut, anterior visceral endoderm, and epithelial structures through Wnt and BMP inhibition. In adults, sFRP-5 is expressed by adipocytes, particularly in white adipose tissue, and acts as an anti-inflammatory adipokine. Shown to improve metabolic function and reduce adipose tissue inflammation, sFRP-5 also acts in a cardio-protective manner after ischemia and reperfusion injury in the heart, suppressing the non-canonical Wnt5a/JNK signaling pathway in macrophages and myocytes. sFRP-5 levels are negatively correlated with obesity-related disorders including insulin resistance, type 2 diabetes, dyslipidemia, atherosclerosis, and coronary artery disease. Downregulation by promoter hypermethylation is observed in numerous cancers including gastric, cervical, hepatocellular carcinoma, pancreatic, oral squamous cell, breast, colon, bladder, and renal. sFRP-5 inhibits melanogenesis when expressed in vitiligo melanocytes. CHO cell-derived Recombinant Human sFRP5 is a 288-amino-acid length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 33-35 kDa by SDS-PAGE analysis under both reducing and non-reducing conditions.
- Formulierung:
- lyophilized
- Host:
- Goat
- Molekulargewicht:
- 32.7 kDa
- Reinheit:
- ≥ 98% by SDS-PAGE gel and HPLC analyses
- Sequenz:
- EEYDYYGWQA EPLHGRSYSK PPQCLDIPAD LPLCHTVGYK RMRLPNLLEH ESLAEVKQQA SSWLPLLAKR CHSDTQVFLC SLFAPVCLDR PIYPCRSLCE AVRAGCAPLM EAYGFPWPEM LHCHKFPLDN DLCIAVQFGH LPATAPPVTK ICAQCEMEHS ADGLMEQMCS SDFVVKMRIK EIKIENGDRK LIGAQKKKKL LKPGPLKRKD TKRLVLHMKN GAGCPCPQLD SLAGSFLVMG RKVDGQLLLM AVYRWDKKNK EMKFAVKFMF SYPCSLYYPF FYGAAEPH
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins