IL-13 (113aa)
Produktgrößen
2ug
£178,82
R20-049S-2UG
Über dieses Produkt
- SKU:
- R20-049S
- Zusätzliche Namen:
- il13
- translate.label.attr.clone:
- (#5H73)
- Weitere Details:
- The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging. Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.
- Formulierung:
- lyophilized
- Host:
- Rat
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature