IL-3 beta
Produktgrößen
5ug
£178,82
R20-006S-5UG
Über dieses Produkt
- SKU:
- R20-006S
- Zusätzliche Namen:
- Il3
- Weitere Details:
- IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.
- Formulierung:
- lyophilized
- Host:
- E. coli
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature