Endothelin-1/ET-1
Produktgrößen
5 ug
£270,59
200-017-5UG
25 ug
£411,76
200-017-25UG
Über dieses Produkt
- SKU:
- 200-017
- Zusätzliche Namen:
- Preproendothelin-1, PPET-1, ET-1, EDN1
- Buffer:
- PBS
- Weitere Details:
- Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
- Formulierung:
- lyophilized from PBS
- Host:
- E. coli
- Immunogen:
- Recombinant Human Endothelin-1
- Molekulargewicht:
- 26.0 kda
- Reinheit:
- > 98% by SDS-PAGE & visualized Coomassie stain
- Reaktivitäten:
- Human
- Sequenz:
- MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins