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Antikörper

TIE-2

Produktgrößen
100 ug
£270,59
103-PA111-100UG
200 ug
£411,76
103-PA111-200UG
Über dieses Produkt
SKU:
103-PA111
Zusätzliche Namen:
Angiopoietin-1 receptor; Endothelial tyrosine kinase; HYK; STK1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; p140 TEK; CD202b; Tek; Hyk; Tie2; AA517024
Anwendung:
Western Blot
Buffer:
PBS
Klonalität:
Polyclonal
Weitere Details:
Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
Formulierung:
lyophilized
Host:
Rabbit
Immunogen:
Recombinant mouse sTIE-2 (RT Cat# S01-M44)
Aufreinigung:
Protein A Purified
Reaktivitäten:
Mouse
Versandbedingungen:
Ambient
Lagerbedingungen:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Typ:
Antibody: Polyclonal Antibody