PIR-B
Produktgrößen
100 ug
£674,12
103-M551-100UG
Über dieses Produkt
- SKU:
- 103-M551
- Zusätzliche Namen:
- Leukocyte immunoglobulin-like receptor, subfamily B (With TM and ITIM domains), member 3, Pirb, Lilrb3
- Anwendung:
- Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3K39
- Klonalität:
- Monoclonal
- Weitere Details:
- Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- Recombinant Mouse PIR-B
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody