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Antikörper

NLRP3

Produktgrößen
100 ug
£674,12
103-M549-100UG
Über dieses Produkt
SKU:
103-M549
Zusätzliche Namen:
NACHT, LRR and PYD domains-containing protein 3, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1
Anwendung:
Immunocytochemistry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
8B16
Klonalität:
Monoclonal
Weitere Details:
NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% and 93% aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.
Formulierung:
lyophilized
Host:
Rat
Immunogen:
Recombinant Mouse NLRP3
Isotyp:
IgG2
Aufreinigung:
Protein G Purified
Versandbedingungen:
Ambient
Lagerbedingungen:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Typ:
Antibody: Monoclonal Antibody