IL-36 alpha
Produktgrößen
100 ug
£674,12
103-M542-100UG
Über dieses Produkt
- SKU:
- 103-M542
- Zusätzliche Namen:
- Interleukin-36A Alpha, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1E Epsilon (FIL1E), Interleukin-1E Epsilon (IL1E)
- Buffer:
- PBS
- translate.label.attr.clone:
- 11G13
- Klonalität:
- Monoclonal
- Weitere Details:
- The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36A Alpha (IL-1F6), B Beta (IL-1F8), and G Gamma (IL-1F9). IL-36A Alpha is highly expressed in psoriatic plaques, as are IL-36B Beta and IL-36G Gamma, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36A Alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36A Alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36A Alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36A Alpha is a 17.2 kDa protein containing 154 amino acid residues.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- Recombinant Mouse IL-36 alpha
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody