P-Selectin
Produktgrößen
100 ug
£674,12
103-M457-100UG
Über dieses Produkt
- SKU:
- 103-M457
- Zusätzliche Namen:
- Selp; Grmp; CD62P; LECAM3; PADGEM; GMP-140
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 17H23
- Klonalität:
- Monoclonal
- Weitere Details:
- Mouse -P-Selectin (GMP140, LECAM3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P- Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or WeibelPalade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL 1 (PSelectin glycoprotein ligand1). PSelectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with LSelectin, PSelectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic 'rolling' of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving ESelectin, and later ICAM1 and VCAM1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue. Mouse P-Selectin cDNA encodes a 768 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 668 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2t-erminal C-type lectin domain and an EGF like domain followedby a series of of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse P-Selectin extracellular domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody