Oncostatin M
Produktgrößen
100 ug
£674,12
103-M446-100UG
Über dieses Produkt
- SKU:
- 103-M446
- Zusätzliche Namen:
- OSM
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7H61
- Klonalität:
- Monoclonal
- Weitere Details:
- Oncostatin M (OSM) is a member of the IL-6 family of cytokines that is produced primarily by activated T cells and macrophages. OSM induces fibroblast proliferation, inhibits tumor cell proliferation, and plays a role in immune regulation. Mouse OSM binds to the OSM receptor B Beta (OSMRB Beta) which forms a heteromeric complex with the common IL-6 family receptor subunit, gp130. In contrast, human OSM binds to two distinct receptor complexes, the OSMRB Beta/gp130 and LIFRB Beta/gp130 complexes. The ability of human OSM to bind to two receptors may explain the overlapping and distinct activities of human OSM and LIF. OSM induces the activation the JAK2, STAT3, and ERK1/2 pathways.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse Oncostatin
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody