IL-6 receptor
Produktgrößen
100 ug
£674,12
103-M255-100UG
Über dieses Produkt
- SKU:
- 103-M255
- Zusätzliche Namen:
- Il6r; CD126; IL-6R
- Anwendung:
- IHC-Frozen, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 14F33
- Klonalität:
- Monoclonal
- Weitere Details:
- The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R) and a signal-transducing component of 130 kDa (gp 130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human and murine IL-6 R alphas have been constructed, however, by insertion of termination codons into the regions of the IL-6 R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6 R alpha complex to membrane-bound gp130.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse IL-6R alpha chain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein A/G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody