DAN
Produktgrößen
100 ug
£674,12
103-M07-100UG
Über dieses Produkt
- SKU:
- 103-M07
- Zusätzliche Namen:
- Nbl1; DAN; NO3; Dana; D4H1S1733E
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 1S42
- Klonalität:
- Monoclonal
- Weitere Details:
- DAN (differential screening-selected gene aberrative in neuroblastoma) was initially identified as a gene whose expression is downregulated in srctransformed rat fibroblasts. DAN has now been shown to be a prototypical member of the DAN family of secreted glycoproteins that are putative BMP antagonists. DAN family members share a cysteinerich domain that is structurally related to the cysteineknot motif found in TGFB Beta superfamily ligands. There are at least five mouse DAN family members, including DAN, Gremlin/DRM, Cer1 (Cerberusrelated), Dante and PRDC (protein-related to DAN and cerberus). Additional DAN family members include Xenopus Cerberus, chick Caronte, and C. elegans CeCan 1. Murine DAN binds BMP2 in immunoprecipitation experiments and acts as a BMP antagonist in Xenopus animal cap explants. The DAN family of proteins are thought to act as antagonists by binding BMP ligands and preventing their interactions with signaling receptor complexes. Recombinant mouse DAN have been shown to bind BMP4 in a functional ELISA. It is likely the various DAN family members and other TGFB Beta BMP antagonists including Noggin, Chordin, Follistatin, and TSG can selectively antagonize the activities of different subsets of TGFB Beta superfamily ligands. These antagonists represent one of the many elaborate regulatory mechanisms that have evolved to control the bioactivities of the TGFB Beta superfamily ligands.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- mouse recombinant DAN
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G/A chromatography
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody