Endothelin-1/ET-1
Produktgrößen
100 ug
£270,59
102-PA35-100UG
200 ug
£411,76
102-PA35-200UG
Über dieses Produkt
- SKU:
- 102-PA35
- Zusätzliche Namen:
- Preproendothelin-1, PPET-1, ET-1, EDN1
- Anwendung:
- Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
- Formulierung:
- lyophilized from PBS
- Host:
- Rabbit
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Polyclonal Antibody