Dkk-1
Produktgrößen
100 ug
£270,59
102-PA33-100UG
200 ug
£411,76
102-PA33-200UG
Über dieses Produkt
- SKU:
- 102-PA33
- Zusätzliche Namen:
- Dickkopf-related protein-1, Dickkopf-1, SK
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- (#7K51)
- Klonalität:
- Polyclonal
- Weitere Details:
- DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /B Beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/B Betacatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/B Betacatenin signaling cascade. It has been suggested that by inhibiting Wnt/B Beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.
- Formulierung:
- lyophilized
- Host:
- Rabbit
- Immunogen:
- recombinant human Dkk-1
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Polyclonal Antibody