CD22
Produktgrößen
100 ug
£365,88
102-P107-100UG
Über dieses Produkt
- SKU:
- 102-P107
- Zusätzliche Namen:
- CD22; SIGLEC2; SIGLEC-2
- Anwendung:
- ELISA, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- (#3F67)
- Klonalität:
- Polyclonal
- Weitere Details:
- Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
- Formulierung:
- lyophilized from PBS
- Host:
- Rabbit
- Immunogen:
- CHO cells derived Recombinant Human sCD22
- Aufreinigung:
- Antigen-affinity purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Polyclonal Antibody