TGF beta R3
Produktgrößen
100 ug
£674,12
101-M836-100UG
Über dieses Produkt
- SKU:
- 101-M836
- Zusätzliche Namen:
- TGFBR3; BGCAN; betaglycan
- Buffer:
- PBS
- translate.label.attr.clone:
- 5G34
- Klonalität:
- Monoclonal
- Weitere Details:
- Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Recombinant human TGF beta RIII extracellular domain
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody