IL-5R alpha EC
Produktgrößen
100 ug
£674,12
101-M792-100UG
Über dieses Produkt
- SKU:
- 101-M792
- Zusätzliche Namen:
- Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA, CDw125, CD125
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6J30
- Klonalität:
- Monoclonal
- Weitere Details:
- Interleukin-5 Receptor alpha (IL-5 R alpha ), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 R alpha consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four-cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5 R alpha shares 71% aa sequence identity with mouse and rat IL-5 R alpha. Alternate splicing of human IL-5 R alpha generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 R alpha and the transmembrane common beta chain (beta c/CD131) which is shared with the receptor complexes for IL-3 and GM-CSF. IL-5 R alpha binds IL-5 at low affinity and then associates with preformed beta c oligomers to form the signalling-competent receptor complex.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant IL-5RalphaEC domain
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody