FRP-3 (secreted)
Produktgrößen
100 ug
£674,12
101-M744-100UG
Über dieses Produkt
- SKU:
- 101-M744
- Zusätzliche Namen:
- Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 9J18
- Klonalität:
- Monoclonal
- Weitere Details:
- Secreted Frizzled Related Protein-3 (sFRP-3), also known as FRZB, belongs to a family of Wnt-binding proteins with homology to the ligand-binding domain of the Frizzled receptors. sFRPs are approximately 30-35 kDa in size and contain an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain. Mature human sFRP-3 shares 93% aa sequence identity with mouse and rat sFRP-3. It neutralizes the bioactivity of Wnt-1, -5a, -9a, Xenopus Xwnt-8, and EGF (5-8). sFRP-3 regulates somitic myogenesis and osteoblast differentiation as well as morphogenesis of the cochlear epithelium, hair follicle, and cardiac atrioventricular cushion. sFRP-3 also functions as a tumor suppressor in a variety of cancers including melanoma, medulloblastoma, soft tissue sarcoma, and androgen-independent prostate cancer. It inhibits epithelial-mesenchymal transition, tumor growth and invasion, and the activity of MMP-2 and MMP-9. In contrast, it can promote tumor growth and angiogenesis in renal cancer.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant sFRP-3
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody