P-Cadherin
Produktgrößen
100 ug
£674,12
101-M601-100UG
Über dieses Produkt
- SKU:
- 101-M601
- Zusätzliche Namen:
- CDH3; CDHP; HJMD; PCAD
- Anwendung:
- Flow Cytometry, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 9V11
- Klonalität:
- Monoclonal
- Weitere Details:
- Placental (P) Cadherin (PCAD) is a member of the Cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, A Alpha, B Beta, and G Gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. P Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a singlepass transmembrane domain, and a short carboxyterminal cytoplasmic domain responsible for interacting with the catenins. Human P Cadherin is an 829 amino acid (aa) protein with a 26 aa signal sequence and an 803 aa propeptide. The mature protein begins at aa 108 and has a 548 aa extracellular region, a 23 aa transmembrane region, and a 151 aa cytoplasmic region. The human and mouse mature PCAD proteins share 87% homology.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human P-Cadherin extracellular domain
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody