MICB
Produktgrößen
100 ug
£674,12
101-M570-100UG
Über dieses Produkt
- SKU:
- 101-M570
- Zusätzliche Namen:
- MICB; PERB11.2
- Anwendung:
- Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3C37
- Klonalität:
- Monoclonal
- Weitere Details:
- MICB (MHC class I chainrelated gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulinlike domains, but have no capacity to bind peptide or interact with B Beta2microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, G GammaD Delta T cells, and CD8+ A AlphaB Beta T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down regulates NKG2D surface expression on effector cells resulting in the impairment of ant-itumor immune response .
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human MICB
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody