CRTAM
Produktgrößen
100 ug
£674,12
101-M343-100UG
Über dieses Produkt
- SKU:
- 101-M343
- Zusätzliche Namen:
- CRTAM; CD355
- Anwendung:
- Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 21A9
- Klonalität:
- Monoclonal
- Weitere Details:
- Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human recombinant CRTAM extracellular domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody