Cathepsin L
Produktgrößen
100 ug
£674,12
101-M250-100UG
Über dieses Produkt
- SKU:
- 101-M250
- Zusätzliche Namen:
- CTSL1; MEP; CATL; CTSL
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6M17
- Klonalität:
- Monoclonal
- Weitere Details:
- Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinasetype plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate A Alpha1 anti trypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth. Human Cathepsin L activity is greatest under mildly acidic conditions, from pH 4.5 to 6.5. The stability of the enzyme decreases at higher pH values.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human Cathepsin-L
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody