Cathepsin D
Produktgrößen
100 ug
£674,12
101-M247-100UG
Über dieses Produkt
- SKU:
- 101-M247
- Zusätzliche Namen:
- CTSD; CPSD; CLN10
- Buffer:
- PBS
- translate.label.attr.clone:
- 13P35
- Klonalität:
- Monoclonal
- Weitere Details:
- Cathepsin D is a lysosomal aspartic protease of the pepsin family (1). Human cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (aa 1-18), a propeptide (aa 19-64), and a mature chain (aa 65-412) ). The mature chain can be processed further to the light (aa 65-161) and heavy (aa 169-412) chains. It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human Cathepsin-D
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody