TIMP-4
Produktgrößen
100 ug
£674,12
101-M126-100UG
Über dieses Produkt
- SKU:
- 101-M126
- Zusätzliche Namen:
- TIMP4
- Anwendung:
- IHC-Paraffin, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 9F3
- Klonalität:
- Monoclonal
- Weitere Details:
- TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human recombinant TIMP-4 protein
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody