Emilin-1
Produktgrößen
100 ug
£270,59
101-M09-100UG
Über dieses Produkt
- SKU:
- 101-M09
- Zusätzliche Namen:
- Elastin microfibril interface-located protein 1, Elastin microfibril interfacer 1, EMI
- Anwendung:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 1H2/G8
- Klonalität:
- Monoclonal
- Weitere Details:
- Emilins (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine-rich EMI domain and a conserved C-terminal gC1q-like domain. Emilin-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as Emilin-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as Emilin-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. Emilin-5 is encoded by the Emilin-3 gene and is sometimes referred to as Emilin-3. It contains the N-terminal cysteine-rich EMI domain but lacks the C-terminal gC1q-like domain. Emilin-1 have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the A Alpha4B Beta1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFB Beta preventing its maturation to mature TGFB Beta in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human Emilin-1
- Isotyp:
- IgG2a
- Aufreinigung:
- Protein-G purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody