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Proteine und Peptide

PDGF-CC

Produktgrößen
5 ug
£178,82
100-354-5UG
20 ug
£307,06
100-354-20UG
Über dieses Produkt
SKU:
100-354
Zusätzliche Namen:
PDGF-CC
Weitere Details:
The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-A Alpha and PDGFR-B Beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet A Alpha-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-RA Alpha receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-RB Beta receptor. Recombinant human PDGF-CC is a 25 kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.
Formulierung:
lyophilized
Host:
E. coli
Molekulargewicht:
25 kDa
Reinheit:
> 98% by SDS-PAGE & HPLC analyses
Reaktivitäten:
Human, Mouse
Sequenz:
MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG
Versandbedingungen:
Ambient
Lagerbedingungen:
Room Temperature
Typ:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins