IL-36 alpha (IL-1F6)
Produktgrößen
2 ug
£178,82
100-160-2UG
10 ug
£307,06
100-160-10UG
Über dieses Produkt
- SKU:
- 100-160
- Zusätzliche Namen:
- Interleukin-36A Alpha, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1E Epsilon (FIL1E), Interleukin-1E Epsilon (IL1E)
- Weitere Details:
- The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36A Alpha (IL-1F6), B Beta (IL-1F8), and G Gamma (IL-1F9). IL-36A Alpha is highly expressed in psoriatic plaques, as are IL-36B Beta and IL-36G Gamma, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36A Alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36A Alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36A Alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36A Alpha is a 17.2 kDa protein containing 154 amino acid residues.
- Formulierung:
- lyophilized
- Host:
- E. coli
- Molekulargewicht:
- 40 kDa
- Reinheit:
- >985 by SDS-PAGE and HPLC analyses
- Reaktivitäten:
- Human
- Sequenz:
- MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins