CD146/MCAM Polyclonal Antibody
Produktgrößen
50 ul
£218,00
RD90756A-50UL
100 ul
£359,00
RD90756A-100UL
Über dieses Produkt
- SKU:
- RD90756A
- Zusätzliche Namen:
- CD146, MCAM, MUC18
- Anwendung:
- Western Blot
- Buffer:
- PBS with 0.02% sodium azide,50% glycerol pH 7.4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein of 113-130 kDa,belonging to the immunoglobulin (Ig) superfamily. Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs). In addition to the membrane-anchored form of CD146,a soluble form of CD146 (sCD146,105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells. This antibody detects a band at approximately 120 kDa that corresponds to the molecular weight of glycosylated CD146. Treatment of lysates of HepG2 cells and L02 cells with PNGase F,which removes oligosaccharides from N-linked glycoproteins,led to a down-shift of the detected band.|This is a CD146/MCAM Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human CD146/MCAM protein expressed by? E.coli
- Isotyp:
- IgG
- Molekulargewicht:
- 43kDa
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Reddot
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:cd146-mcam-polyclonal-antibody-33098.html