anti-Synaptopodin, guinea pig polyclonal antibody
Produktgrößen
100 ul
£394,00
GP94-IN-100UL
Über dieses Produkt
- SKU:
- GP94-IN
- Zusätzliche Namen:
- Synaptopodin, SYNPO, KIAA1029
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- Klonalität:
- Polyclonal
- Weitere Details:
- The antibody reacts specifically with an epitope in the internal part of synaptopodin/SYNPO, a prolin-rich actin-binding protein with 2 binding sites for actin. Synaptopodin belongs to actin-binding pro-teins, it has first been localized in podocytes and a subset of telencephalic postsynaptic densities. In human tissue synaptopodin has a molecular weight of 73.7 kD and pI of 9.38 (calculated from sequence data); in mouse the corre-sponding data are 74 kD, pI 9.27. In SDS-PAGE the antigen appears as 100 kD polypeptide in brain and 110 kD polypeptide in kidney (attributed to posttransla-tional modifications). In Western blot analysis the antibody also reacts with a 44 kD degradation fragment of synaptopodin. The antibody recognizes differentiated podocytes (glomerular visceral epithelial cells) in vivo and in vitro (weaker additional reaction with arterial endothelial cells), co-localization with alpha-actinin. Reacts with a subset of exclusively telencephalic synapses. Differentiation-dependent expression during postnatal maturation of murine brain. Differentiation-dependent expression in cultured hippocampal neurons.
- Formulierung:
- Contains 0.09% sodium azide and 0.5% BSA
- Host:
- Guinea Pig
- Immunogen:
- Synthetic peptides (mouse internal central sequence), coupled to KLH
- Aufreinigung:
- Stabilized antiserum
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Please refer to datasheet
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GP94-IN
