anti-Drebrin, guinea pig polyclonal antibody
Produktgrößen
100 ul
£354,00
GP254-100UL
Über dieses Produkt
- SKU:
- GP254
- Zusätzliche Namen:
- Drebrin, Developmentally-regulated brain protein, DBN1, D0S117E
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- Klonalität:
- Polyclonal
- Weitere Details:
- The antiserum specifically reacts with drebrin, a widespread actin-associating protein of 70 kD (SDS-PAGE mobility shows Mr 120,000). Drebrin has originally been described only in neuronal cells, but has been recently found also in the actin-rich lamellipodia and filopodia of motile cells. It is enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. Positive staining was found in many tissues, including diverse epithelia and carcinoma (e.g. in epidermis basal cells are positive, whereas overlying cells are negative; also positive: regenerating epithelium during wound healing; basal cell carcinoma; skin melanoma), specific types of endothelia and smooth muscle; especially prominent in the mesangial cells of renal glomeruli and in the Sertoli cells of testis. Also positive: epithelia of hair follicles and eccrine sweat glands. Consistently negative were, however, hepatocytes and cross-striated muscle. Positive cultured cell lines: PLC, U333, HUVEC, HaCat, HeLa, MCF-7, SV-80, B1; B16 (mouse melanoma cells)
- Formulierung:
- Contains 0.09% sodium azide
- Host:
- Guinea Pig
- Immunogen:
- Synthetic human peptide (aa 254-272) coupled to KLH
- Aufreinigung:
- Stabilized antiserum
- Reaktivitäten:
- Bovine, Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Please refer to datasheet
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GP254