anti-CD33 / SIGLEC3, 33-20, mouse monoclonal antibody
Produktgrößen
100 ug
£432,00
691576-100UG
Über dieses Produkt
- SKU:
- 691576
- Zusätzliche Namen:
- Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD antigen CD33, CD33, SIGLEC3
- Anwendung:
- FACS, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 33-20
- Klonalität:
- Monoclonal
- Konzentration:
- 100 ug/ml
- Weitere Details:
- CD33 is a 67 kDa glycoprotein of the sialic acid-binding immunoglobulin-like lectin (SIGLEC) family, displaying the immune-receptor tyrosine-based inhibitory motif (ITIM), able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic linage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. Positive control: human dendritic and mast cells. Human lymph node and tonsil.
- Formulierung:
- PBS with 0.02% sodium azide
- Host:
- Mouse
- Immunogen:
- Stimulated human AML cells
- Isotyp:
- IgG1, kappa
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Please refer to datasheet
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:691576
