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Antikörper

anti-LDL Receptor, IgG-C7, mouse monoclonal antibody

Produktgrößen
50 ug
£315,00
61087-50UG
Über dieses Produkt
SKU:
61087
Zusätzliche Namen:
Low-density lipoprotein receptor, LDL receptor, LDLR
Anwendung:
Immunocytochemistry, Immunofluorescence
CE/IVD:
RUO
translate.label.attr.clone:
IgG-C7
Klonalität:
Monoclonal
Konzentration:
50 ug/ml
Weitere Details:
Suitable for analysis of LDL receptor function in patients with familial hypercholesterolemia. The antibody recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibody results in inhibition of half-maximal LDL-binding (Beisiegel et al. 1981). In human normal fibroblasts the antibody detects the 160 kDa polypeptide (pI 4.3) and also in bovine adrenal gland (160 kDa; pI 4.6) of LDL receptors (Beisiegel et al. 1982). Beisiegelt, U., Schneider, W. J., Brown, M. S. & Goldstein, J. L. Immunoblot Analysis of Low Density Lipoprotein Receptors in Fibroblasts from Subjects with Familial Hypercholesterolemia. J. Biol. Chem. 257, 13150-13156 (1982). Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G. & Brown, M. S. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J. Biol. Chem. 256, 11923-31 (1981).
Formulierung:
Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
Host:
Mouse
Immunogen:
Purified bovine adrenal cortex LDL receptor
Isotyp:
IgG2b, kappa
Physischer Zustand:
Lyophilized
Aufreinigung:
Affinity Purified
Reaktivitäten:
Bovine, Canine, Hamster, Human, Mouse, Rabbit, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
Typ:
Antibody: Monoclonal Antibody
  • Datenblatt des Herstellers:61087