DF-006
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DF-006
£ POA
HY-176507
Über dieses Produkt
- SKU:
- HY-176507
- Weitere Details:
- DF-006 is a first-in-class orally active agonist of ALPK1 (α-kinase 1). DF-006 can stimulate the innate immune response by activating the NF-κB pathway and strongly stimulate the innate immunity in the liver locally. DF-006 reduces the levels of serum HBV DNA (EC50 = 2.7 pM), HBsAg and HBeAg, and has shown strong antiviral effects. DF-006 is suitable for research on the immunotherapy of chronic hepatitis B (CHB)[1].
- Molekulargewicht:
- 791.54
- Referenzen:
- [1]1. Xu C et al. Alpha-kinase 1 (ALPK1) agonist DF-006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B. Hepatology. 2023 Jan 1;77(1):275-289. doi: 10.1002 https://pubmed.ncbi.nlm.nih.gov/35699669/|[2]1. Xu C et al. Alpha-kinase 1 (ALPK1) agonist DF-006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B. Hepatology. 2023 Jan 1;77(1):275-289. doi: 10.1002
- Forschungsgebiet:
- Infection; Inflammation/Immunology
- Versandbedingungen:
- Ambient