Grazoprevir (Standard)
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Grazoprevir (Standard)
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HY-15298R
Über dieses Produkt
- SKU:
- HY-15298R
- CAS Number:
- 1350514-68-9
- Weitere Details:
- Grazoprevir (Standard) is the analytical standard of Grazoprevir. This product is intended for research and analytical applications. Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir inhibits SARS-CoV-2 3CLpro activity[3].
- Molekulargewicht:
- 766.9
- Referenzen:
- [1]Summa V, et al. MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.|[2]Harper S, et al. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6.|[3]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
- Forschungsgebiet:
- Infection
- Versandbedingungen:
- Ambient