Human NRG1 / Heregulin / Neuregulin Protein (Recombinant)
Produktgrößen
10 units
£ POA
LS-G27136-10UNITS
50 units
£ POA
LS-G27136-50UNITS
Über dieses Produkt
- SKU:
- LS-G27136
- Zusätzliche Namen:
- NRG1, ARIA, GGF, GGF2, Glial growth factor, Heregulin, HRGA, MSTP131, NDF, Neu differentiation factor, Neuregulin 1 type IV beta 3, Neuregulin 1 type IV beta 1a, HRG1, NRG-1, SMDF, Neuregulin 1, Pro-NRG1, HGL, MST131
- Buffer:
- Lyophilized from PBS
- Weitere Details:
- Heregulin1-Beta1(HRG1-Beta1) is one of the isoforms encoded by Neuregulin (NRG) genes. NRGs are synthesized as large transmembrane precursor proteins, and the NRG family has 4 members and 26 isoforms. These isoforms provide large diversities, including different tissue distribution, variable potencies, and different biological functions. HRG1-Beta1 belongs to Type I HRG1, and is expressed in neural tissue, respiratory epithelia, and heart. In vivo, HRG1 binds and activates both ErbB3 and ErbB4, the transmembrane receptor tyrosine kinase, and is involved in the proliferation, differentiation, and survival of cells. Aberrantly produced HRG1 could be used in the constitute activation of the ErbB receptors; therefore, the upregulation of HRG1 contributes to the development of tumors, including breast cancer.Recombinant human Heregulin1-Beta1(HRG1-Beta1) produced in E. coli is a single non-glycosylated polypeptide chain containing 66 amino acids. A fully biologically active molecule, rh HRG1-Beta1 has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Molekulargewicht:
- 7.6 kDa (SDS-PAGE)
- Physischer Zustand:
- Lyophilized
- Reinheit:
- >95%
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles., 2-8[o]C reconstituted.
- Hersteller:
- LifeSpan Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:27136