Human MMP8 Protein (Recombinant 10His, C-terminus)
Produktgrößen
1 mg
£ POA
LS-G137914-1MG
10 ug
£ POA
LS-G137914-10UG
50 ug
£ POA
LS-G137914-50UG
500 ug
£ POA
LS-G137914-500UG
Über dieses Produkt
- SKU:
- LS-G137914
- Zusätzliche Namen:
- MMP8, CLG1, HNC, Matrix metalloproteinase-8, MMP-8, Neutrophil collagenase, PMNL collagenase, PMNL-CL
- Buffer:
- Lyophilized from a sterile solution in 50 mM Tris-HCl, pH 7.5, 10 mM CaCl2, 150 mM NaCl
- Weitere Details:
- Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-a and GM-CSF. MMP8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, B Beta-casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain. MMP8 is heavily glycosylated.
- Physischer Zustand:
- Lyophilized
- Reinheit:
- >90%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- 2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles., RT Aliquot. Avoid freeze/thaw cycles., -20[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- LifeSpan Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:137914