Cynomolgus HAVCR2 / TIM-3 Protein (Recombinant 8His, N-terminus)
Produktgrößen
1 mg
£ POA
LS-G137908-1MG
10 ug
£ POA
LS-G137908-10UG
50 ug
£ POA
LS-G137908-50UG
500 ug
£ POA
LS-G137908-500UG
Über dieses Produkt
- SKU:
- LS-G137908
- Zusätzliche Namen:
- HAVCR2, HAVcr-2, KIM-3, Kidney injury molecule-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, T-cell membrane protein 3, TIM3, TIMD-3, T cell immunoglobulin mucin-3, CD366
- Buffer:
- Lyophilized from a sterile solution in PBS, pH 7.4.
- Weitere Details:
- T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
- Physischer Zustand:
- Lyophilized
- Reinheit:
- >95%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- 2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles., RT Aliquot. Avoid freeze/thaw cycles., -20[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- LifeSpan Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:137908