Human IGFBP7 / TAF Protein (Recombinant 6His, C-terminus)
Produktgrößen
1 mg
£ POA
LS-G137882-1MG
10 ug
£ POA
LS-G137882-10UG
50 ug
£ POA
LS-G137882-50UG
500 ug
£ POA
LS-G137882-500UG
Über dieses Produkt
- SKU:
- LS-G137882
- Zusätzliche Namen:
- IGFBP7, AGM, FSTL2, IGFBP-7v, IGFBP-rP1, IBP-7, Angiomodulin, RAMSVPS, MAC25 protein, PSF, TAF, Tumor-derived adhesion factor, IGF-binding protein 7, IGFBP-7, IGFBPRP1, MAC25, PGI2-stimulating factor
- Buffer:
- Lyophilized from a sterile solution in PBS, pH 7.4.
- Weitere Details:
- Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.
- Physischer Zustand:
- Lyophilized
- Reinheit:
- >95%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- 2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles., RT Aliquot. Avoid freeze/thaw cycles., -20[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- LifeSpan Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:137882